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Requip

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Trial 1 was a 12-week multicenter trial where 63 patients with idiopathic Parkinson's illness receiving concomitant anti-Parkinson treatment (however not L-dopa) were signed up and also 41 were randomized to Requip as well as 22 to inactive medicine. Individuals had a mean disease period of approximately 2 years. If they presented with bradykinesia and at the very least trembling, rigidness, or postural instability, patients were qualified for registration. Additionally, they should have been identified as Hoehn & Yahr Stage I-IV. This scale, varying from I = independent participation with marginal impairment to V = confined to mobility device or bed, is a conventional tool made use of for hosting people with Parkinson's illness. The main outcome action in this test was the proportion of people experiencing a reduction (contrasted with baseline) of at the very least 30 % in the UPDRS electric motor rating.



Clients were titrated for approximately 10 weeks, beginning at 0.5 mg two times daily, with regular increments of 0.5 mg twice daily to an optimum of 5 mg two times daily. Once clients reached their maximally allowed dose (or 5 mg twice daily), they were maintained on that dose through 12 weeks. The mean dosage attained by clients at trial endpoint was 7.4 mg/day. Mean standard UPDRS motor rating was 18.6 for individuals treated with Requip and also 19.9 for people treated with placebo. At the end of 12 weeks, the portion of -responders was greater on Requip compared to on placebo and the difference was statistically substantial (Table 6).

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